Epigenetic regulation of persistent pain.
نویسندگان
چکیده
Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development or maintenance of persistent pain and possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.
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ورودعنوان ژورنال:
- Translational research : the journal of laboratory and clinical medicine
دوره 165 1 شماره
صفحات -
تاریخ انتشار 2015